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KMID : 0616120030340010045
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Korean Journal of Pharmacognosy
2003 Volume.34 No. 1 p.45 ~ p.54
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Studies on the Processing of Crude Drugs(7) - On the Constituents and Biological Activities of Gardeniae Fructus by Processing -
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신용욱/Shin YW
김동현/김남재/Kim DH/Kim NJ
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Abstract
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We have conducted to characterize the physico-chemical change and pharmacological transformation of traditional herbal medicines by means of processing. Processed Gardeniae Fructus was prepared by heating of fruit of Gardenia jasminoides(GF) for 30∼50 minute in the roster designed for herb processing. The content of drying loss, water extract, diluted ethanol extract, ether extract and geniposide in non-processed GF and processed GF were examined. The contents of drying loss, water extract and geniposide in processed GF showed a decrease as compared with those of non-processed GF, however the content of dilute ethanol and ether extract showed a increase as compared with those of non-processed GF. The rate of decrease/increase of those index were in proportion to heating time. And, biological activities of methanol extract of non-processed GF and processed GF were investigated. DPPH scavenging effects and inhibitory effect of xanthine oxidase and hemolysis of processed GF exhibited more effective than those of non-processed GF in vitro. Accelerating effect of large intestinal transport and purgative action of non-processed GF were discriminated by processing of GF. Methanol extracts of non-processed GF and processed GF showed the protective effects against the hepatotoxicity induces by α-naphthylisothiocyanate in rates. These results suggested that the transformation of biological activities of GF by means of processing may be due to the physico-chemical change of the constituents in GF by heating.
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KEYWORD
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Gardenia jasminoides, herb processing, geniposide, antioxidative, purgative, hepatoprotective
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